Cave of septum pellucidum

Brain: Cave of septum pellucidum

Stylized horizontal section through the brain showing normal and cavum septum pellucidum.

Difference between cavum septum pellucidum (CSP), cavum vergae (CV), and cavum velum interpositi (CVI). 3=third ventricle, 4=fourth ventricle.
Latin	cavum septi pellucidi
Gray's	subject #189 840

Cavum septum pellucidum (CSP) describes a septum pellucidum that has a separation between its two leaflets (septal laminae). This cavity contains cerebrospinal fluid (CSF) that filters from the ventricles through the septal laminae ^[1].

CSP is bounded anteriorly by the genu of the corpus callosum; superiorly by the body of the corpus callosum; posteriorly by the anterior limb and pillars of the fornix; inferiorly by the anterior commissure and the rostrum of the corpus callosum; and laterally by the leaflets of the septum pellucidum ^[2].

The most common type of CSP is noncommunicating, that is, it does not connect to the brain's ventricular system. Because of this lack of communication, the erstwhile term for CSP, the "fifth ventricle," is not anatomically correct and its use has fallen out of favor in recent years.

CSP is present in 100% of fetuses, but over 85% of them fuse by 3–6 months after birth ^[3]^[4]. It has been loosely associated with schizophrenia, post-traumatic stress disorder, and chronic brain trauma ^[5] ^[6] ^[7].

1 References in movies
2 See also
3 References
4 External links

References in movies

In Rocky V, Rocky Balboa is notified he has Cavum septum pellucidum.

References

^ Oteruelo F (1986). "On the cavum septi pellucidi and the cavum Vergae". Anatomischer Anzeiger 162 (4): 271–8. PMID 3813041.
^ Born C, Meisenzahl E, Frodl T, Pfluger T, Reiser M, Möller H, Leinsinger G (2004). "The septum pellucidum and its variants. An MRI study". European archives of psychiatry and clinical neuroscience 254 (5): 295–302. doi:10.1007/s00406-004-0496-z. PMID 15365704.
^ Farruggia S, Babcock D (1981). "The cavum septi pellucidi: its appearance and incidence with cranial ultrasonography in infancy". Radiology 139 (1): 147–50. PMID 7208915.
^ "Paediatric Imaging: Cavum septum pellucidum". Medcyclopedia.com. http://www.medcyclopaedia.com/library/topics/volume_vii/c/cavum_septum_pellucidum.aspx.
^ May F, Chen Q, Gilbertson M, Shenton M, Pitman R (2004). "Cavum septum pellucidum in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder". Biol. Psychiatry 55 (6): 656–8. doi:10.1016/j.biopsych.2003.09.018. PMC 2794416. PMID 15013837. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2794416.
^ Galarza M, Merlo A, Ingratta A, Albanese E, Albanese A (2004). "Cavum septum pellucidum and its increased prevalence in schizophrenia: a neuroembryological classification". The Journal of neuropsychiatry and clinical neurosciences 16 (1): 41–6. doi:10.1176/appi.neuropsych.16.1.41. PMID 14990758.
^ Zhang L, Ravdin L, Relkin N, Zimmerman R, Jordan B, Lathan W, Uluğ A (2003). "Increased diffusion in the brain of professional boxers: a preclinical sign of traumatic brain injury?". AJNR. American journal of neuroradiology 24 (1): 52–7. PMID 12533327.